Researching Human Diseases through Animal Models
The Whitehead Institute


Whitehead Member Rudolf Jaenisch’s laboratory created the first transgenic mouse model of a severe human disease and developed fundamental tools—now used by researchers everywhere—to grow human cells and tissues in animal models to test the effects of drug treatment. With his colleagues, Jaenisch, an outspoken critic of human reproductive cloning, used these tools to reverse immune disease in mice using a combination of therapeutic cloning, gene therapy, and embryonic stem cell manipulation.